How Long-Term Steroid Use Affects the Hypothalamic Pituitary Axis

Long-term steroid use suppresses your Hypothalamic Pituitary Axis by mimicking natural cortisol, causing your brain to reduce hormone production. It leads to decreased CRH from your hypothalamus and reduced ACTH from your pituitary gland. Over weeks to months, your adrenal glands atrophy, resulting in symptoms like fatigue, weakness, and poor stress response. Recovery varies from […]

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